Cephalosporins 1945–1986

@article{Abraham2012Cephalosporins1,
  title={Cephalosporins 1945–1986},
  author={Edward P. Abraham},
  journal={Drugs},
  year={2012},
  volume={34},
  pages={1-14}
}
SummaryIn 1945, after penicillin had been introduced into medicine, an antibiotic-producing species of Cephalosporium was isolated from a sewage outfall in Sardinia. Four years later in Oxford, this organism was found to produce several antibiotics, one of which was a penicillin with a new side-chain, penicillin N. During a chemical study in 1953, this penicillin was shown to be contaminated with a second substance, cephalosporin C, which contained a β-lactam ring but was resistant to… 
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