Cephalosporin C acylase: dream and(/or) reality

@article{Pollegioni2013CephalosporinCA,
  title={Cephalosporin C acylase: dream and(/or) reality},
  author={Loredano Pollegioni and Elena Rosini and Gianluca Molla},
  journal={Applied Microbiology and Biotechnology},
  year={2013},
  volume={97},
  pages={2341-2355}
}
  • Loredano Pollegioni, Elena Rosini, Gianluca Molla
  • Published in
    Applied Microbiology and…
    2013
  • Medicine, Chemistry
  • Cephalosporins currently constitute the most widely prescribed class of antibiotics and are used to treat diseases caused by both Gram-positive and Gram-negative bacteria. Cephalosporins contain a 7-aminocephalosporanic acid (7-ACA) nucleus which is derived from cephalosporin C (CephC). The 7-ACA nucleus is not sufficiently potent for clinical use; however, a series of highly effective antibiotic agents could be produced by modifying the side chains linked to the 7-ACA nucleus. The industrial… CONTINUE READING

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