Cep72 regulates the localization of key centrosomal proteins and proper bipolar spindle formation

  title={Cep72 regulates the localization of key centrosomal proteins and proper bipolar spindle formation},
  author={Naoki Oshimori and X. Li and M. Ohsugi and T. Yamamoto},
  journal={The EMBO Journal},
  • Naoki Oshimori, X. Li, +1 author T. Yamamoto
  • Published 2009
  • Biology, Medicine
  • The EMBO Journal
  • Microtubule‐nucleation activity and structural integrity of the centrosome are critical for various cellular functions. The γ‐tubulin ring complexes (γTuRCs) localizing to the pericentriolar matrix (PCM) of the centrosome are major sites of microtubule nucleation. The PCM is thought to be created by two cognate large coiled‐coil proteins, pericentrin/kendrin and CG‐NAP/AKAP450, and its stabilization by Kizuna is essential for bipolar spindle formation. However, the mechanisms by which these… CONTINUE READING
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