Cep72 regulates the localization of key centrosomal proteins and proper bipolar spindle formation.

@article{Oshimori2009Cep72RT,
  title={Cep72 regulates the localization of key centrosomal proteins and proper bipolar spindle formation.},
  author={Naoki Oshimori and Xue Li and Miho Ohsugi and Tadashi Yamamoto},
  journal={The EMBO journal},
  year={2009},
  volume={28 14},
  pages={
          2066-76
        }
}
Microtubule-nucleation activity and structural integrity of the centrosome are critical for various cellular functions. The gamma-tubulin ring complexes (gammaTuRCs) localizing to the pericentriolar matrix (PCM) of the centrosome are major sites of microtubule nucleation. The PCM is thought to be created by two cognate large coiled-coil proteins, pericentrin/kendrin and CG-NAP/AKAP450, and its stabilization by Kizuna is essential for bipolar spindle formation. However, the mechanisms by which… CONTINUE READING
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