Cep164 triggers ciliogenesis by recruiting Tau tubulin kinase 2 to the mother centriole.

Abstract

Primary cilia play critical roles in development and disease. Their assembly is triggered by mature centrioles (basal bodies) and requires centrosomal protein 164kDa (Cep164), a component of distal appendages. Here we show that loss of Cep164 leads to early defects in ciliogenesis, reminiscent of the phenotypic consequences of mutations in TTBK2 (Tau… (More)
DOI: 10.1073/pnas.1401777111

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