Cep164, a novel centriole appendage protein required for primary cilium formation

  title={Cep164, a novel centriole appendage protein required for primary cilium formation},
  author={Susanne Graser and York-Dieter Stierhof and S{\'e}bastien B. Lavoie and Oliver S. Gassner and Stefan Lamla and Mikael Le Clech and Erich A. Nigg},
  journal={The Journal of Cell Biology},
  pages={321 - 330}
Primary cilia (PC) function as microtubule-based sensory antennae projecting from the surface of many eukaryotic cells. They play important roles in mechano- and chemosensory perception and their dysfunction is implicated in developmental disorders and severe diseases. The basal body that functions in PC assembly is derived from the mature centriole, a component of the centrosome. Through a small interfering RNA screen we found several centrosomal proteins (Ceps) to be involved in PC formation… CONTINUE READING
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