Centrosomin represses dendrite branching by orienting microtubule nucleation

@article{Yalgin2015CentrosominRD,
  title={Centrosomin represses dendrite branching by orienting microtubule nucleation},
  author={Cagri Yalgin and Saman Ebrahimi and Caroline Delandre and Li Foong Yoong and Saori Akimoto and Heidi Tran and Reiko Amikura and Rebecca Fran Spokony and Benjamin Torben-Nielsen and Kevin P. White and Adrian W. Moore},
  journal={Nature Neuroscience},
  year={2015},
  volume={18},
  pages={1437-1445}
}
Neuronal dendrite branching is fundamental for building nervous systems. Branch formation is genetically encoded by transcriptional programs to create dendrite arbor morphological diversity for complex neuronal functions. In Drosophila sensory neurons, the transcription factor Abrupt represses branching via an unknown effector pathway. Targeted screening for branching-control effectors identified Centrosomin, the primary centrosome-associated protein for mitotic spindle maturation. Centrosomin… CONTINUE READING
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