Centrosome number is controlled by a centrosome-intrinsic block to reduplication

Abstract

The centrosome duplicates once in S phase. To determine whether there is a block in centrosome reduplication, we used a cell fusion assay to compare the duplication potential of unduplicated G1 centrosomes and recently duplicated G2 centrosomes. By fusing cells in different cell cycle stages, we found that G2 centrosomes were unable to reduplicate in a… (More)
DOI: 10.1038/ncb993

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