Centrosome motility is essential for initial axon formation in the neocortex.

  title={Centrosome motility is essential for initial axon formation in the neocortex.},
  author={Froylan Calderon de Anda and Konstantinos Meletis and Xuecai Ge and Damien Rei and Li-Huei Tsai},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={30 31},
The mechanisms underlying the normal development of neuronal morphology remain a fundamental question in neurobiology. Studies in cultured neurons have suggested that the position of the centrosome and the Golgi may predict the site of axon outgrowth. During neuronal migration in the developing cortex, however, the centrosome and Golgi are oriented toward the cortical plate at a time when axons grow toward the ventricular zone. In the current work, we use in situ live imaging to demonstrate… CONTINUE READING
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