Centrosome-independent mitotic spindle formation in vertebrates

@article{Khodjakov2000CentrosomeindependentMS,
  title={Centrosome-independent mitotic spindle formation in vertebrates},
  author={A. Khodjakov and R. Cole and B. Oakley and C. Rieder},
  journal={Current Biology},
  year={2000},
  volume={10},
  pages={59-67}
}
BACKGROUND In cells lacking centrosomes, the microtubule-organizing activity of the centrosome is substituted for by the combined action of chromatin and molecular motors. The question of whether a centrosome-independent pathway for spindle formation exists in vertebrate somatic cells, which always contain centrosomes, remains unanswered, however. By a combination of labeling with green fluorescent protein (GFP) and laser microsurgery we have been able to selectively destroy centrosomes in… Expand
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