Centrosome dynamics as a source of chromosomal instability.

  title={Centrosome dynamics as a source of chromosomal instability.},
  author={Hyun-Ja Nam and Ryan Naylor and Jan M van Deursen},
  journal={Trends in cell biology},
  volume={25 2},
Accurate segregation of duplicated chromosomes between two daughter cells depends on bipolar spindle formation, a metaphase state in which sister kinetochores are attached to microtubules emanating from opposite spindle poles. To ensure bi-orientation, cells possess surveillance systems that safeguard against microtubule-kinetochore attachment defects, including the spindle assembly checkpoint and the error correction machinery. However, recent developments have identified centrosome dynamics… CONTINUE READING
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