Centrosome duplication continues in cycloheximide-treated Xenopus blastulae in the absence of a detectable cell cycle

Abstract

Cycloheximide (500 micrograms/ml) rapidly arrests cleavage, spindle assembly, and cycles of an M-phase-specific histone kinase in early Xenopus blastulae. 2 h after cycloheximide addition, most cells contained two microtubule asters radiating from perinuclear microtubule organizing centers (MTOCs). In contrast, blastomeres treated with cycloheximide for… (More)

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@article{Gard1990CentrosomeDC, title={Centrosome duplication continues in cycloheximide-treated Xenopus blastulae in the absence of a detectable cell cycle}, author={David L. Gard and Sara Hafezi and Taiqi Zhang and Stephen John Doxsey}, journal={The Journal of Cell Biology}, year={1990}, volume={110}, pages={2033 - 2042} }