Centrosome disorganization in fibroblast cultures derived from R6/2 Huntington's disease (HD) transgenic mice and HD patients.

@article{Sathasivam2001CentrosomeDI,
  title={Centrosome disorganization in fibroblast cultures derived from R6/2 Huntington's disease (HD) transgenic mice and HD patients.},
  author={Kirupa Sathasivam and Bridget Woodman and Amarbirpal Mahal and Fabien Bertaux and Erich E. Wanker and David T. Shima and Gillian P Bates},
  journal={Human molecular genetics},
  year={2001},
  volume={10 21},
  pages={
          2425-35
        }
}
Huntington's disease (HD) is a progressive neurological disorder caused by a CAG/polyglutamine repeat expansion. We have previously generated the R6/2 mouse model that expresses exon 1 of the human HD gene containing CAG repeats in excess of 150. These mice develop a progressive neurological phenotype with a rapid onset and progression. We show here that it is impossible to establish fibroblast lines from these mice at 12 weeks of age, whilst this can be achieved without difficulty at 6 and 9… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 64 CITATIONS, ESTIMATED Infinity% COVERAGE

64 Citations

02468'02'05'09'13'17
Citations per Year
Semantic Scholar estimates that this publication has 64 citations based on the available data.

See our FAQ for additional information.

Similar Papers

Loading similar papers…