Centrosome abnormalities during a Chlamydia trachomatis infection are caused by dysregulation of the normal duplication pathway.

@article{Johnson2009CentrosomeAD,
  title={Centrosome abnormalities during a Chlamydia trachomatis infection are caused by dysregulation of the normal duplication pathway.},
  author={Kirsten A. Johnson and Ming Tan and Christine S{\"u}tterlin},
  journal={Cellular microbiology},
  year={2009},
  volume={11 7},
  pages={1064-73}
}
The presence of supernumerary centrosomes in cells infected with Chlamydia trachomatis may provide a mechanism to explain the association of C. trachomatis genital infection with cervical cancer. We show that the amplified centrosomal foci induced during a chlamydial infection contain both centriolar and pericentriolar matrix markers, demonstrating that they are bona fide centrosomes. As there were multiple immature centrioles but approximately one mature centriole per cell, aborted cytokinesis… CONTINUE READING
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