Centrosome abnormalities and genomic instability induced by human papillomavirus oncoproteins.

@article{Duensing2003CentrosomeAA,
  title={Centrosome abnormalities and genomic instability induced by human papillomavirus oncoproteins.},
  author={Stefan Duensing and Karl M{\"u}nger},
  journal={Progress in cell cycle research},
  year={2003},
  volume={5},
  pages={383-91}
}
Cervical cancer is tightly associated with infection by high-risk human papillomaviruses (HPVs). Many high-risk HPV-positive lesions are genomically unstable and show chromosomal gains and losses already at early stages of carcinogenic progression. These genomic aberrations are caused by the HPV-encoded oncoproteins E6 and E7, which subvert mitotic fidelity of the infected host cell. Whereas E7 drives genomic instability by inducing abnormal centrosome numbers, E6 cooperates with E7 presumably… CONTINUE READING

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