Centrosomal localization of DNA damage checkpoint proteins.

  title={Centrosomal localization of DNA damage checkpoint proteins.},
  author={Suisheng Zhang and Peter H. Hemmerich and F. Grosse},
  journal={Journal of cellular biochemistry},
  volume={101 2},
During mitosis, the phosphatidylinositol-3 (PI-3) family-related DNA damage checkpoint kinases ATM and ATR were found on the centrosomes of human cells. ATRIP, an interaction partner of ATR, as well as Chk1 and Chk2, the downstream targets of ATR or ATM, were also localized to the centrosomes. Surprisingly, the DNA-PK inhibitor vanillin enhanced the level of ATM on centrosomes. Accordingly, DNA-PKcs, the catalytic subunit of DNA-PK, was also found on the centrosomes. Vanillin altered the… CONTINUE READING