Centrophilin: a novel mitotic spindle protein involved in microtubule nucleation

  title={Centrophilin: a novel mitotic spindle protein involved in microtubule nucleation},
  author={Albert Tousson and Changqing Zeng and Bill R. Brinkley and Manuel Mart{\'i}nez Valdivia},
  journal={The Journal of Cell Biology},
  pages={427 - 440}
A novel protein has been identified which may serve a key function in nucleating spindle microtubule growth in mitosis. This protein, called centrophilin, is sequentially relocated from the centromeres to the centrosomes to the midbody in a manner dependent on the mitotic phase. Centrophilin was initially detected by immunofluorescence with a monoclonal, primate-specific antibody (2D3) raised against kinetochore-enriched chromosome extract from HeLa cells (Valdivia, M. M., and B. R. Brinkley… CONTINUE READING


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