Centromeric Satellite DNAs: Hidden Sequence Variation in the Human Population

@inproceedings{Miga2019CentromericSD,
  title={Centromeric Satellite DNAs: Hidden Sequence Variation in the Human Population},
  author={Karen H. Miga},
  booktitle={Genes},
  year={2019}
}
The central goal of medical genomics is to understand the inherited basis of sequence variation that underlies human physiology, evolution, and disease. Functional association studies currently ignore millions of bases that span each centromeric region and acrocentric short arm. These regions are enriched in long arrays of tandem repeats, or satellite DNAs, that are known to vary extensively in copy number and repeat structure in the human population. Satellite sequence variation in the human… CONTINUE READING
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References

Publications referenced by this paper.
SHOWING 1-10 OF 104 REFERENCES

A whole-genome admixture scan finds a candidate locus for multiple sclerosis susceptibility

David Reich, Nick Patterson, +17 authors David A Hafler
  • Nature Genetics
  • 2005
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

A global reference for human genetic variation

Jespersen, Jakob Berg
  • Nature
  • 2015
VIEW 7 EXCERPTS
HIGHLY INFLUENTIAL