Centromere targeting of the chromosomal passenger complex requires a ternary subcomplex of Borealin, Survivin, and the N-terminal domain of INCENP.

@article{Klein2006CentromereTO,
  title={Centromere targeting of the chromosomal passenger complex requires a ternary subcomplex of Borealin, Survivin, and the N-terminal domain of INCENP.},
  author={U. Klein and E. Nigg and U. Gruneberg},
  journal={Molecular biology of the cell},
  year={2006},
  volume={17 6},
  pages={
          2547-58
        }
}
The chromosomal passenger complex (CPC), consisting of the serine/threonine kinase Aurora B, the inner centromere protein INCENP, Survivin, and Borealin/DasraB, has essential functions at the centromere in ensuring correct chromosome alignment and segregation. Despite observations that small interfering RNA-mediated knockdown of any one member of the CPC abolishes localization of the other subunits, it remains unclear how the complex is targeted to the centromere. We have now identified a… Expand
The Ins and Outs of Aurora B Inner Centromere Localization
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Relocation of Aurora B from centromeres to the central spindle at the metaphase to anaphase transition requires MKlp2
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