Centromere replication timing determines different forms of genomic instability in Saccharomyces cerevisiae checkpoint mutants during replication stress.

@article{Feng2009CentromereRT,
  title={Centromere replication timing determines different forms of genomic instability in Saccharomyces cerevisiae checkpoint mutants during replication stress.},
  author={Wenyi Feng and Jeff Bachant and David Collingwood and M. K. Raghuraman and Bonita J. Brewer},
  journal={Genetics},
  year={2009},
  volume={183 4},
  pages={1249-60}
}
Yeast replication checkpoint mutants lose viability following transient exposure to hydroxyurea, a replication-impeding drug. In an effort to understand the basis for this lethality, we discovered that different events are responsible for inviability in checkpoint-deficient cells harboring mutations in the mec1 and rad53 genes. By monitoring genomewide replication dynamics of cells exposed to hydroxyurea, we show that cells with a checkpoint deficient allele of RAD53, rad53K227A, fail to… CONTINUE READING
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