Centromere clustering is a major determinant of yeast interphase nuclear organization.

@article{Jin2000CentromereCI,
  title={Centromere clustering is a major determinant of yeast interphase nuclear organization.},
  author={Qichen Jin and J{\"o}rg Fuchs and Josef Loidl},
  journal={Journal of cell science},
  year={2000},
  volume={113 ( Pt 11)},
  pages={
          1903-12
        }
}
During interphase in the budding yeast, Saccharomyces cerevisiae, centromeres are clustered near one pole of the nucleus as a rosette with the spindle pole body at its hub. Opposite to the centromeric pole is the nucleolus. Chromosome arms extend outwards from the centromeric pole and are preferentially directed towards the opposite pole. Centromere clustering is reduced by the ndc10 mutation, which affects a kinetochore protein, and by the microtubule poison nocodazole. This suggests that… CONTINUE READING

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