Centromere-associated protein E: a motor that puts the brakes on the mitotic checkpoint.

  title={Centromere-associated protein E: a motor that puts the brakes on the mitotic checkpoint.},
  author={K. Wood and Penelope R Chua and David E. Sutton and Jeffrey R. Jackson},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  volume={14 23},
Cell cycle checkpoints have long been recognized as important nodes for regulating cell proliferation and maintaining genomic integrity. These checkpoints are often altered in cancer and represent promising points for therapeutic intervention. Until recently, direct targeting of the mitotic checkpoint has been an untapped area for cancer drug discovery. Regulation of the mitotic checkpoint is complex, but many of the critical players have been identified and functionally characterized. A… CONTINUE READING


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