Centromere activity in dicentric small supernumerary marker chromosomes

@article{Ewers2010CentromereAI,
  title={Centromere activity in dicentric small supernumerary marker chromosomes},
  author={Elisabeth Ewers and Kinya Yoda and Ahmed Basheer Hamid and Anja Weise and Marina Manvelyan and Thomas Liehr},
  journal={Chromosome Research},
  year={2010},
  volume={18},
  pages={555-562}
}
Twenty-five dicentric small supernumerary marker chromosomes (sSMC) derived from #13/21, #14, #15, #18, and #22 were studied by immunohistochemistry for their centromeric activity. Centromere protein (CENP)-B was applied as marker for all centromeres and CENP-C to label the active ones. Three different ‘predominant’ activation patterns could be observed, i.e., centric fusion or either only one or all two centromeres were active. In one inherited case, the same activation pattern was found in… CONTINUE READING
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