Centromere RNA is a key component for the assembly of nucleoproteins at the nucleolus and centromere.

@article{Wong2007CentromereRI,
  title={Centromere RNA is a key component for the assembly of nucleoproteins at the nucleolus and centromere.},
  author={Lee Hwa Wong and Kate H. Brettingham-Moore and Lyn Chan and Julie M. Quach and Melissa A. Anderson and Emma L. Northrop and Ross A Hannan and Richard Saffery and Margaret L Shaw and Evan Williams and K. H. Andy Choo},
  journal={Genome research},
  year={2007},
  volume={17 8},
  pages={1146-60}
}
The centromere is a complex structure, the components and assembly pathway of which remain inadequately defined. Here, we demonstrate that centromeric alpha-satellite RNA and proteins CENPC1 and INCENP accumulate in the human interphase nucleolus in an RNA polymerase I-dependent manner. The nucleolar targeting of CENPC1 and INCENP requires alpha-satellite RNA, as evident from the delocalization of both proteins from the nucleolus in RNase-treated cells, and the nucleolar relocalization of these… CONTINUE READING
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