Centripetal myosin redistribution in thrombin-stimulated platelets. Relationship to platelet Factor 4 secretion.

@article{Painter1984CentripetalMR,
  title={Centripetal myosin redistribution in thrombin-stimulated platelets. Relationship to platelet Factor 4 secretion.},
  author={Richard G. Painter and Mark H. Ginsberg},
  journal={Experimental cell research},
  year={1984},
  volume={155 1},
  pages={
          198-212
        }
}
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  • 1993
TLDR
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  • Biology
    Advances in experimental medicine and biology
  • 1993
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Data show that the platelet cytoskeleton interacts with select SNAREs and that actin polymerization facilitates alpha-granule release.
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    Journal of thrombosis and haemostasis : JTH
  • 2015
TLDR
This review summarizes the current knowledge of the molecular mechanism leading to platelet shape change, with a special emphasis on microtubules, and refers to previously published observations, which have been essential for generating an integrated view of cytoskeletal rearrangements during platelet activation.
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TLDR
It is concluded that filamentous actin may be involved in structuring of the cortex and in cytoplasmic streaming, and may therefore influence the formation, and possibly the transcellular transport (cyclosis), of food vacuoles, as well as the docking of trichocysts, whereas it does not play a role in exocytosis per se or in the steps immediately following.
Anatomy of the Platelet Cytoskeleton
TLDR
This chapter reviews the cellular mechanisms and proteins maintaining the morphology of resting and activated platelets, focusing on the actin cytoskeleton and exciting recent mRNA and protein profiling studies, clinical observations, and mouse models.
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Ulastructural examination of thrombin-treated platelets revealed vacuoles corresponding in size, shape, and time of occurrence to the large immunofluorescent masses of PF4, which appear to represent the ultrastructureural counterpart of the large PF4 masses.
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