Centriole Reduplication during Prolonged Interphase Requires Procentriole Maturation Governed by Plk1

@article{Loncarek2010CentrioleRD,
  title={Centriole Reduplication during Prolonged Interphase Requires Procentriole Maturation Governed by Plk1},
  author={Jadranka Loncarek and Polla J. Hergert and Alexey Khodjakov},
  journal={Current Biology},
  year={2010},
  volume={20},
  pages={1277-1282}
}
Supernumerary centrioles lead to abnormal mitosis, which in turn promotes tumorigenesis. Thus, centriole duplication must be coordinated with the cell cycle to ensure that the number of centrioles in the cell doubles precisely during each cell cycle. However, in some transformed cells, centrioles undergo multiple rounds of duplication (reduplication) during… CONTINUE READING