Centriolar satellite– and hMsd1/SSX2IP-dependent microtubule anchoring is critical for centriole assembly

@inproceedings{Hori2015CentriolarSA,
  title={Centriolar satellite– and hMsd1/SSX2IP-dependent microtubule anchoring is critical for centriole assembly},
  author={Akiko Hori and Christopher J. Peddie and Lucy M. Collinson and Takashi Toda and Stephen Doxsey},
  booktitle={Molecular biology of the cell},
  year={2015}
}
Centriolar satellites are numerous electron-dense granules dispersed around the centrosome. Mutations in their components are linked to various human diseases, but their molecular roles remain elusive. In particular, the significance of spatial communication between centriolar satellites and the centrosome is unknown. hMsd1/SSX2IP localizes to both the centrosome and centriolar satellites and is required for tethering microtubules to the centrosome. Here we show that hMsd1/SSX2IP-mediated… CONTINUE READING
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