Centriolar SAS-5 is required for centrosome duplication in C. elegans

@article{Delattre2004CentriolarSI,
  title={Centriolar SAS-5 is required for centrosome duplication in C. elegans},
  author={Marie Delattre and Sebastian Leidel and Khursheed Wani and Karine Baumer and Jeannine Bamat and Heinke Schnabel and Richard Feichtinger and Ralf Schnabel and Pierre G{\"o}nczy},
  journal={Nature Cell Biology},
  year={2004},
  volume={6},
  pages={656-664}
}
Centrosomes, the major microtubule-organizing centres (MTOCs) of animal cells, are comprised of a pair of centrioles surrounded by pericentriolar material (PCM). Early in the cell cycle, there is a single centrosome, which duplicates during S-phase to direct bipolar spindle assembly during mitosis. Although crucial for proper cell division, the mechanisms that govern centrosome duplication are not fully understood. Here, we identify the Caenorhabditis elegans gene sas-5 as essential for… CONTINUE READING
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