Centrin/Cdc31 is a novel regulator of protein degradation.

  title={Centrin/Cdc31 is a novel regulator of protein degradation.},
  author={Li Chieh Chen and Kiran Madura},
  journal={Molecular and cellular biology},
  volume={28 5},
Rad23 is required for efficient protein degradation and performs an important role in nucleotide excision repair. Saccharomyces cerevisiae Rad23, and its human counterpart (hHR23), are present in a complex containing the DNA repair factor Rad4 (termed XPC, for xeroderma pigmentosum group C, in humans). XPC/hHR23 was also reported to bind centrin-2, a member of the superfamily of calcium-binding EF-hand proteins. We report here that yeast centrin, which is encoded by CDC31, is similarly present… CONTINUE READING
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