Centralspindlin regulates ECT2 and RhoA accumulation at the equatorial cortex during cytokinesis.

@article{Nishimura2006CentralspindlinRE,
  title={Centralspindlin regulates ECT2 and RhoA accumulation at the equatorial cortex during cytokinesis.},
  author={Yukako Nishimura and Shigenobu Yonemura},
  journal={Journal of cell science},
  year={2006},
  volume={119 Pt 1},
  pages={104-14}
}
During determination of the cell division plane, an actomyosin contractile ring is induced at the equatorial cell cortex by signals from the mitotic apparatus and contracts to cause cleavage furrow progression. Although the small GTPase RhoA is known to regulate the progression, probably by controlling actin filament assembly and enhancing actomyosin interaction, any involvement of RhoA in division plane determination is unknown. In this study, using a trichloroacetic acid (TCA) fixation… CONTINUE READING
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