Centrally truncated and stabilized porcine neuropeptide Y analogs: design, synthesis, and mouse brain receptor binding.

@article{Krstenansky1989CentrallyTA,
  title={Centrally truncated and stabilized porcine neuropeptide Y analogs: design, synthesis, and mouse brain receptor binding.},
  author={John L. Krstenansky and Thomas J. Owen and Stephen H. Buck and Karen A. Hagaman and Larry R. McLean},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1989},
  volume={86 12},
  pages={
          4377-81
        }
}
Porcine neuropeptide Y (pNPY) has been proposed to form an intramolecularly stabilized structure characterized by N- and C-terminal helical regions arranged antiparallel due to a central turn region. Analogs based on this structural model that have the central turn region and various amounts of the helical regions removed, yet retain the N and C termini in a similar spatial orientation were designed. The gap formed by removal of the central residues (residues 8-17 or 7-20) was spanned with a… CONTINUE READING

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