Centrally active antimuscarinic analogs of oxotremorine selectively block physostigmine-induced hypertension, but not peripheral muscarinic vasodepression.

H. Vargas; B. Ringdahl

Corpus ID: 28063326

Centrally active antimuscarinic analogs of oxotremorine selectively block physostigmine-induced hypertension, but not peripheral muscarinic vasodepression.

@article{Vargas1990CentrallyAA,
  title={Centrally active antimuscarinic analogs of oxotremorine selectively block physostigmine-induced hypertension, but not peripheral muscarinic vasodepression.},
  author={H. Vargas and B. Ringdahl},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1990},
  volume={253 1},
  pages={
          165-70
        }
}

H. Vargas, B. Ringdahl

Published 1990

Medicine

The Journal of pharmacology and experimental therapeutics

Some tertiary antimuscarinic amines related to oxotremorine were compared with atropine and scopolamine for their ability to block physostigmine-induced hypertension and acetylcholine-induced hypotension in rats. These cardiovascular responses are mediated via muscarinic receptors in the brainstem and on the vasculature, respectively. In urethane-anesthetized rats, physostigmine (77 nmol/kg i.v.) increased mean arterial pressure 40 +/- 5 mm Hg. One hour later, each rat received a single dose of… CONTINUE READING

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