• Corpus ID: 28063326

Centrally active antimuscarinic analogs of oxotremorine selectively block physostigmine-induced hypertension, but not peripheral muscarinic vasodepression.

@article{Vargas1990CentrallyAA,
  title={Centrally active antimuscarinic analogs of oxotremorine selectively block physostigmine-induced hypertension, but not peripheral muscarinic vasodepression.},
  author={H M Vargas and Bj{\"o}rn Ringdahl},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1990},
  volume={253 1},
  pages={
          165-70
        }
}
  • H. Vargas, B. Ringdahl
  • Published 1 April 1990
  • Biology, Medicine, Chemistry
  • The Journal of pharmacology and experimental therapeutics
Some tertiary antimuscarinic amines related to oxotremorine were compared with atropine and scopolamine for their ability to block physostigmine-induced hypertension and acetylcholine-induced hypotension in rats. These cardiovascular responses are mediated via muscarinic receptors in the brainstem and on the vasculature, respectively. In urethane-anesthetized rats, physostigmine (77 nmol/kg i.v.) increased mean arterial pressure 40 +/- 5 mm Hg. One hour later, each rat received a single dose of… 
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