Centrally acting non-narcotic antitussives prevent hyperactivity in mice: Involvement of GIRK channels

@article{Soeda2016CentrallyAN,
  title={Centrally acting non-narcotic antitussives prevent hyperactivity in mice: Involvement of GIRK channels},
  author={F. Soeda and Y. Fujieda and M. Kinoshita and T. Shirasaki and K. Takahama},
  journal={Pharmacology Biochemistry and Behavior},
  year={2016},
  volume={144},
  pages={26-32}
}
  • F. Soeda, Y. Fujieda, +2 authors K. Takahama
  • Published 2016
  • Medicine
  • Pharmacology Biochemistry and Behavior
  • We have previously reported that centrally acting non-narcotic antitussives inhibited G protein-coupled inwardly rectifying potassium (GIRK) channel-activated currents, and that the antitussives had multiple pharmacological actions on various models of intractable brain diseases in rodents. In this study, the question of whether these antitussives inhibit drug-induced hyperactivity in mice was investigated. Antitussives, such as cloperastine and tipepidine, at cough suppressant doses, inhibited… CONTINUE READING
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