Centrality of Striatal Cholinergic Transmission in Basal Ganglia Function

  title={Centrality of Striatal Cholinergic Transmission in Basal Ganglia Function},
  author={Paola Bonsi and Dario Cuomo and Giuseppina Martella and Graziella Madeo and Tommaso Schirinzi and Francesca Puglisi and Giulia Ponterio and Antonio Pisani},
  booktitle={Front. Neuroanat.},
Work over the past two decades revealed a previously unexpected role for striatal cholinergic interneurons in the context of basal ganglia function. The recognition that these interneurons are essential in synaptic plasticity and motor learning represents a significant step ahead in deciphering how the striatum processes cortical inputs, and why pathological circumstances cause motor dysfunction. Loss of the reciprocal modulation between dopaminergic inputs and the intrinsic cholinergic… CONTINUE READING


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