Central versus peripheral impact of estradiol on the impaired glucose metabolism in ovariectomized mice on a high-fat diet.

@article{Yonezawa2012CentralVP,
  title={Central versus peripheral impact of estradiol on the impaired glucose metabolism in ovariectomized mice on a high-fat diet.},
  author={Rika Yonezawa and Tsutomu Wada and Natsumi Matsumoto and Mayuko Morita and Kanae Sawakawa and Yoko Ishii and Masakiyo Sasahara and Hiroshi Tsuneki and Shigeru Saito and Toshiyasu Sasaoka},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2012},
  volume={303 4},
  pages={E445-56}
}
Age-related loss of ovarian function promotes adiposity and insulin resistance in women. Estrogen (E(2)) directly enhances insulin sensitivity and suppresses lipogenesis in peripheral tissues. Recently, the central actions of E(2) in the regulation of energy homeostasis are becoming clearer; however, the functional relevance and degree of contribution of the central vs. peripheral actions of E(2) are currently unknown. Therefore, we prepared and analyzed four groups of mice. 1) CONTROL: sham… CONTINUE READING
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Effects of high-fat diet on plasma lipids, adiposity, and inflammatory markers in ovariectomized C57BL/6 mice

  • Ludgero-Correia A, MB Aguila, CA Mandarim-de-Lacerda, TS Faria
  • Nutrition
  • 2012
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