Central tolerance to self-antigen expressed by cortical epithelial cells.

@article{Mayerova2004CentralTT,
  title={Central tolerance to self-antigen expressed by cortical epithelial cells.},
  author={Dita Mayerova and Kristin A Hogquist},
  journal={Journal of immunology},
  year={2004},
  volume={172 2},
  pages={851-6}
}
The exposure of developing thymocytes to high-affinity self-Ag results in T cell tolerance. A predominant mechanism for this is clonal deletion; though receptor editing, anergy induction, and positive selection of regulatory T cells have also been described. It is unclear what signals are involved in determining different tolerance mechanisms. In particular, OT-I mice displayed receptor editing when the high-affinity self-Ag was expressed in cortical epithelial cells (cEC) using the human… CONTINUE READING