Central thalamic deep brain stimulation for cognitive neuromodulation - a review of proposed mechanisms and investigational studies.

@article{Shah2010CentralTD,
  title={Central thalamic deep brain stimulation for cognitive neuromodulation - a review of proposed mechanisms and investigational studies.},
  author={Sudhin A. Shah and Nicholas D. Schiff},
  journal={The European journal of neuroscience},
  year={2010},
  volume={32 7},
  pages={
          1135-44
        }
}
We review the history of efforts to apply central thalamic deep brain stimulation (CT/DBS) to restore consciousness in patients in a coma or vegetative state by changing the arousal state. Early experimental and clinical studies, and the results of a recent single-subject human study that demonstrated both immediate behavioral facilitation and carry-over effects of CT/DBS are reviewed. We consider possible mechanisms underlying CT/DBS effects on cognitively-mediated behaviors in conscious… CONTINUE READING

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