Central serotonin transporter availability in highly obese individuals compared with non-obese controls: A [11C] DASB positron emission tomography study

@article{Hesse2015CentralST,
  title={Central serotonin transporter availability in highly obese individuals compared with non-obese controls: A [11C] DASB positron emission tomography study},
  author={Swen Hesse and Michael Rullmann and Julia Luthardt and Karsten Winter and Mohammed K. Hankir and G. Becker and Franziska Zientek and Georg Reissig and Ralf Regenthal and Mandy Drabe and Christian Schinke and Anke Bresch and Katrin Ar{\'e}lin and Donald Lobsien and Marianne Patt and Philipp M. Meyer and Mathias Fasshauer and Wiebke K Fenske and Matthias Bl{\"u}her and Michael Stumvoll and Osama Sabri},
  journal={European Journal of Nuclear Medicine and Molecular Imaging},
  year={2015},
  volume={43},
  pages={1096-1104}
}
The role of the central serotonin (5-hydroxytryptamine, 5-HT) system in feeding has been extensively studied in animals with the 5-HT family of transporters (5-HTT) being identified as key molecules in the regulation of satiety and body weight. Aberrant 5-HT transmission has been implicated in the pathogenesis of human obesity by in vivo positron emission tomography (PET) and single-photon emission computed tomography (SPECT) imaging techniques. However, results obtained thus far from studies… CONTINUE READING