Central serotonergic neurons activate and recruit thermogenic brown and beige fat and regulate glucose and lipid homeostasis.

@article{McGlashon2015CentralSN,
  title={Central serotonergic neurons activate and recruit thermogenic brown and beige fat and regulate glucose and lipid homeostasis.},
  author={Jacob M McGlashon and Michelle C. Gorecki and Amanda E Kozlowski and Caitlin K Thirnbeck and Kathleen R Markan and Kirstie L Leslie and Maya E. Kotas and Matthew J Potthoff and George B Richerson and Matthew Paul Gillum},
  journal={Cell metabolism},
  year={2015},
  volume={21 5},
  pages={692-705}
}
Thermogenic brown and beige adipocytes convert chemical energy to heat by metabolizing glucose and lipids. Serotonin (5-HT) neurons in the CNS are essential for thermoregulation and accordingly may control metabolic activity of thermogenic fat. To test this, we generated mice in which the human diphtheria toxin receptor (DTR) was selectively expressed in central 5-HT neurons. Treatment with diphtheria toxin (DT) eliminated 5-HT neurons and caused loss of thermoregulation, brown adipose tissue… CONTINUE READING
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