Central sensitization versus synaptic long-term potentiation (LTP): a critical comment.

read with interest the chapter, ‘‘ActivityDependent Central Sensitization and Synaptic Plasticity,’’ in the recent review article by Latrémolière and Woolf in The Journal of Pain. I noticed a number of issues in that chapter which deserve some discussion. These include the concept of synaptic longterm potentiation in pain pathways and its relation to the… CONTINUE READING