Central sensitization in medullary dorsal horn involves gap junctions and hemichannels

@article{Chiang2010CentralSI,
  title={Central sensitization in medullary dorsal horn involves gap junctions and hemichannels},
  author={Chen Yu Chiang and Zhaohui Li and Jonathan O. Dostrovsky and Barry John Sessle},
  journal={NeuroReport},
  year={2010},
  volume={21},
  pages={233-237}
}
Central sensitization is a fundamental mechanism contributing to acute and chronic pain conditions. Our previous studies have documented a glutamatergic, purinergic and glial-dependent central sensitization that can be induced in rat medullary dorsal horn nociceptive neurons by mustard oil application to the tooth pulp. This study showed that carbenoxolone, a potent gap junction and hemichannel blocker, completely blocked all parameters of mustard oil-induced central sensitization tested in… 

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