Central sensitization in chronic pain and medically unexplained symptom research: A systematic review of definitions, operationalizations and measurement instruments.

@article{denBoer2019CentralSI,
  title={Central sensitization in chronic pain and medically unexplained symptom research: A systematic review of definitions, operationalizations and measurement instruments.},
  author={Carine den Boer and Linne Dries and Berend Terluin and Johannes C. van der Wouden and Annette H. Blankenstein and Cornelis P van Wilgen and Peter Lucassen and Henri{\"e}tte E. van der Horst},
  journal={Journal of psychosomatic research},
  year={2019},
  volume={117},
  pages={
          32-40
        }
}
View on PubMed
doi.org
55 Citations
Highly Influential Citations
1
Background Citations
16
Methods Citations
2

55 Citations

Central Sensitization in Neurological, Psychiatric, and Pain Disorders: A Multicenter Case-Controlled Study
TLDR
The findings suggest that CSS may participate in refractory pain-related diseases as common pathophysiology as well as neurological, psychological, and pain disorders as normal.
Tests for central sensitization in general practice: a Delphi study
TLDR
An inventory of tests for measuring CS was made and three tests were considered to be suitable for use in general practice: the Central Sensitization Inventory (CSI), pressure pain thresholds (PPTs) and monofilaments.
Central Sensitization Inventory is a useless instrument for detection of the impairment of the conditioned pain modulation in patients with chronic musculoskeletal pain.
Central sensitization and functioning in patients with chronic low back pain: A cross-sectional and longitudinal study
TLDR
CS was weakly related to functioning, and decreases in CS were weakly-moderately related to increases in functioning.
Central sensitization inventory scores correlate with pain at rest in patients with hip osteoarthritis: a retrospective study
TLDR
In this study, 1 out of every 20 hip OA patients had CS components, and CSI scores were significantly correlated with pain at rest in Hip OApatients.
A pilot study in the association between Waddell Non-organic Signs and Central Sensitization.
The Definition, Assessment, and Prevalence of (Human Assumed) Central Sensitisation in Patients with Chronic Low Back Pain: A Systematic Review
TLDR
This review uncovered twenty quantitative methods to assess HACS, including four questionnaires and sixteen quantitative sensory testing measures, and found most of the assessment methods are not validated but have been tested for reliability and repeatability.
Pain at Rest as a Predictive Factor of Chronic Pain Related to Central Sensitization in Patients With Hip Osteoarthritis
TLDR
Twenty-one percent of the patients scheduled to undergo total hip arthroplasty for hip OA were diagnosed with chronic pain related to CS, which might influence the clinical results after THA.
Experiences of general practitioners explaining central sensitisation to patients with persistent physical symptoms: a focus group study
TLDR
The use of the CS model seemed to improve the understanding and acceptance of the symptoms by the patients and seemed to reduce their need for more diagnostic tests, and patients seemed to become more motivated to accept appropriate therapy.
Hyperalgesia and Central Sensitization in Subjects With Chronic Orofacial Pain: Analysis of Pain Thresholds and EEG Biomarkers
Introduction: The presence of a temporomandibular disorder is one of the most frequent causes of orofacial pain (OFP). When pain continues beyond tissue healing time, it becomes chronic and may be…
...
...

References

SHOWING 1-10 OF 142 REFERENCES
Evidence for central sensitization in patients with osteoarthritis pain: A systematic literature review
TLDR
Overall results suggest that, although peripheral mechanisms are involved in OA pain, hypersensitivity of the CNS plays a significant role in a subgroup of subjects within this population of patients.
The Central Sensitization Inventory (CSI): establishing clinically significant values for identifying central sensitivity syndromes in an outpatient chronic pain sample.
The Development and Psychometric Validation of the Central Sensitization Inventory
TLDR
2 studies demonstrate the psychometric strength, clinical utility, and the initial construct validity of the CSI in evaluating CS‐related clinical symptoms in chronic pain populations.
Ability of the Central Sensitization Inventory to Identify Central Sensitivity Syndromes in an Outpatient Chronic Pain Sample
TLDR
The CSI is a useful and valid instrument for screening patients for the possibility of a CSS, although the chances of false positives are relatively high when evaluating patients with complex pain and psychophysiological disorders.
The role of central sensitization in shoulder pain: A systematic literature review.
Neurobiological Mechanisms Underlying Chronic Whiplash Associated Pain: The Peripheral Maintenance of Central Sensitization
TLDR
The current neurophysiologic basis for the chronic pain experience, as it may apply to chronic whiplash is reviewed, to indicate that there may be some individuals whose traumatic event may have sensitized certain neurophysiological processes to interpret as pain, from experiences of otherwise ordinary sensory-perception events.
Editorial Review (Thematic Issue: An Update on Central Sensitivity Syndromes and the Issues of Nosology and Psychobiology)
TLDR
Central sensitization (CS), simply defined as an amplified response of the central nervous system to peripheral input, is a concept of great importance in clinical medicine and has helped to explain aspects of the pathophysiology of common diseases, e.g. fibromyalgia syndrome, osteoarthritis, rheumatoid arthritis and post-operative pain.
Measurement Properties of the Central Sensitization Inventory: A Systematic Review
TLDR
The purpose of this systematic review was to gather published studies of a widely used outcome measure (the Central Sensitization Inventory), determine the quality of evidence these publications reported, and examine the measurement properties of the CSI.
Lack of evidence for central sensitization in idiopathic, non-traumatic neck pain: a systematic review.
TLDR
The available evidence suggests that CS is not a major feature of chronic idiopathic neck pain and individual cases might have CS pain, but further work should reveal how they can be characterized.
Central Sensitization and Altered Central Pain Processing in Chronic Low Back Pain: Fact or Myth?
TLDR
It is tempting to speculate that ongoing nociception is associated with cortical and subcortical reorganization and may play an important role in the process of the chronification of LBP.
...
...