Central sensitization and LTP: do pain and memory share similar mechanisms?

@article{Ji2003CentralSA,
  title={Central sensitization and LTP: do pain and memory share similar mechanisms?},
  author={R. Ji and T. Kohno and K. Moore and C. Woolf},
  journal={Trends in Neurosciences},
  year={2003},
  volume={26},
  pages={696-705}
}
Synaptic plasticity is fundamental to many neurobiological functions, including memory and pain. Central sensitization refers to the increased synaptic efficacy established in somatosensory neurons in the dorsal horn of the spinal cord following intense peripheral noxious stimuli, tissue injury or nerve damage. This heightened synaptic transmission leads to a reduction in pain threshold, an amplification of pain responses and a spread of pain sensitivity to non-injured areas. In the cortex, LTP… Expand
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