Central sensitivity and fibromyalgia

  title={Central sensitivity and fibromyalgia},
  author={Veronica Mezhov and Emma K. Guymer and Geoffrey Owen Littlejohn},
  journal={Internal Medicine Journal},
Fibromyalgia presents with symptoms of widespread pain, fatigue, sleeping and cognitive disturbances as well as other somatic symptoms. It often overlaps with other conditions termed ‘central sensitivity syndromes’, such as irritable bowel syndrome, chronic fatigue syndrome and temporomandibular disorder. Central sensitisation, mediated by amplified processing in the central nervous system, has been identified as the key pathogenic mechanism in these disorders. The term ‘central sensitivity… 
Neutrophils infiltrate sensory ganglia and mediate chronic widespread pain in fibromyalgia
It is shown that neutrophils invade sensory ganglia and confer mechanical hypersensitivity on recipient mice, whilst adoptive transfer of immunoglobulin, serum, lymphocytes or monocytes have no effect on pain behaviour, providing the framework for an immunological basis of chronic widespread pain in fibromyalgia mediated by polymorphonuclear granulocytes.
Autism and chronic ill health: an observational study of symptoms and diagnoses of central sensitivity syndromes in autistic adults
Investigation of the occurrence of CSS diagnoses and symptoms in autistic adults found Autistic women were more likely to report a CSS diagnosis and experienced more CSS symptoms than men, and sensory sensitivity, anxiety, age and gender were significant predictors of CSS symptoms.


Fibromyalgia: an update on clinical characteristics, aetiopathogenesis and treatment
Different clinical aspects of fibromyalgia are outlined, including the burden, diagnosis and treatment of this condition, and various hypotheses of fibroitalgia etiopathogenesis are discussed.
Fibrofog and fibromyalgia: a narrative review and implications for clinical practice
Although the pathophysiology of fibromyalgia remains an enigma, evidence suggests that it may be a brain disorder, with cognitive deficits (“fibrofog”) reflecting disturbed centrally mediated processes.
Comorbid fibromyalgia: A qualitative review of prevalence and importance
This qualitative review examines the evidence for comorbid FM in illness, and where available the effect of FM on the primary disease and warns physicians to be alert to the possibility of comorbrid FM.
Central Processes Underlying Fibromyalgia
Fibromyalgia is a common disorder that affects 3–5% of most studied populations, and the resultant burden of disease is high, with a significant impact on personal, recreational, work, and study activities.
Editorial review: an update on central sensitivity syndromes and the issues of nosology and psychobiology.
  • M. Yunus
  • Medicine, Psychology
    Current rheumatology reviews
  • 2015
Central sensitization, simply defined as an amplified response of the central nervous system to peripheral input, is a concept of great importance in clinical medicine and has helped to explain aspects of the pathophysiology of common diseases, e.g. fibromyalgia syndrome, osteoarthritis, rheumatoid arthritis and post-operative pain.
Cognitive deficits in fibromyalgia syndrome are associated with pain responses to low intensity pressure stimulation
It is concluded that pain experience during somatosensory stimulation of low intensity is more closely related to attention, memory and executive functions in FMS than the traditional measures of pain threshold and pain tolerance.
Assessing our approach to diagnosing Fibromyalgia
  • K. Hackshaw
  • Medicine
    Expert review of molecular diagnostics
  • 2020
A discussion of ongoing efforts to obtain a biomarker to enhance diagnostic accuracy and a need to include rheumatologists as part of the care team of patients with Fibromyalgia is emphasized.
Is fibromyalgia a distinct clinical entity? Historical and epidemiological evidence.
  • S. Wessely, M. Hotopf
  • Medicine, Psychology
    Bailliere's best practice & research. Clinical rheumatology
  • 1999
Evidence is presented to suggest that fibromyalgia is not a unique clinical entity, but shares much with other medically unexplained syndromes which have more similarities than differences between them.