Central sensitivity and fibromyalgia

@article{Mezhov2021CentralSA,
  title={Central sensitivity and fibromyalgia},
  author={Veronica Mezhov and Emma K. Guymer and Geoffrey Owen Littlejohn},
  journal={Internal Medicine Journal},
  year={2021},
  volume={51}
}
Fibromyalgia presents with symptoms of widespread pain, fatigue, sleeping and cognitive disturbances as well as other somatic symptoms. It often overlaps with other conditions termed ‘central sensitivity syndromes’, such as irritable bowel syndrome, chronic fatigue syndrome and temporomandibular disorder. Central sensitisation, mediated by amplified processing in the central nervous system, has been identified as the key pathogenic mechanism in these disorders. The term ‘central sensitivity… 
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2 Citations

Neutrophils infiltrate sensory ganglia and mediate chronic widespread pain in fibromyalgia
TLDR
It is shown that neutrophils invade sensory ganglia and confer mechanical hypersensitivity on recipient mice, whilst adoptive transfer of immunoglobulin, serum, lymphocytes or monocytes have no effect on pain behaviour, providing the framework for an immunological basis of chronic widespread pain in fibromyalgia mediated by polymorphonuclear granulocytes.
Autism and chronic ill health: an observational study of symptoms and diagnoses of central sensitivity syndromes in autistic adults
TLDR
Investigation of the occurrence of CSS diagnoses and symptoms in autistic adults found Autistic women were more likely to report a CSS diagnosis and experienced more CSS symptoms than men, and sensory sensitivity, anxiety, age and gender were significant predictors of CSS symptoms.

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