Central sensitivity and fibromyalgia

@article{Mezhov2021CentralSA,
  title={Central sensitivity and fibromyalgia},
  author={Veronica Mezhov and Emma K. Guymer and Geoffrey Owen Littlejohn},
  journal={Internal Medicine Journal},
  year={2021},
  volume={51}
}
Fibromyalgia presents with symptoms of widespread pain, fatigue, sleeping and cognitive disturbances as well as other somatic symptoms. It often overlaps with other conditions termed ‘central sensitivity syndromes’, such as irritable bowel syndrome, chronic fatigue syndrome and temporomandibular disorder. Central sensitisation, mediated by amplified processing in the central nervous system, has been identified as the key pathogenic mechanism in these disorders. The term ‘central sensitivity… 
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References

SHOWING 1-10 OF 57 REFERENCES
Fibromyalgia: an update on clinical characteristics, aetiopathogenesis and treatment
TLDR
Different clinical aspects of fibromyalgia are outlined, including the burden, diagnosis and treatment of this condition, and various hypotheses of fibroitalgia etiopathogenesis are discussed.
Fibrofog and fibromyalgia: a narrative review and implications for clinical practice
TLDR
Although the pathophysiology of fibromyalgia remains an enigma, evidence suggests that it may be a brain disorder, with cognitive deficits (“fibrofog”) reflecting disturbed centrally mediated processes.
Comorbid fibromyalgia: A qualitative review of prevalence and importance
TLDR
This qualitative review examines the evidence for comorbid FM in illness, and where available the effect of FM on the primary disease and warns physicians to be alert to the possibility of comorbrid FM.
Central Processes Underlying Fibromyalgia
TLDR
Fibromyalgia is a common disorder that affects 3–5% of most studied populations, and the resultant burden of disease is high, with a significant impact on personal, recreational, work, and study activities.
Editorial review: an update on central sensitivity syndromes and the issues of nosology and psychobiology.
  • M. Yunus
  • Medicine, Psychology
    Current rheumatology reviews
  • 2015
TLDR
Central sensitization, simply defined as an amplified response of the central nervous system to peripheral input, is a concept of great importance in clinical medicine and has helped to explain aspects of the pathophysiology of common diseases, e.g. fibromyalgia syndrome, osteoarthritis, rheumatoid arthritis and post-operative pain.
Cognitive deficits in fibromyalgia syndrome are associated with pain responses to low intensity pressure stimulation
TLDR
It is concluded that pain experience during somatosensory stimulation of low intensity is more closely related to attention, memory and executive functions in FMS than the traditional measures of pain threshold and pain tolerance.
Assessing our approach to diagnosing Fibromyalgia
  • K. Hackshaw
  • Medicine
    Expert review of molecular diagnostics
  • 2020
TLDR
A discussion of ongoing efforts to obtain a biomarker to enhance diagnostic accuracy and a need to include rheumatologists as part of the care team of patients with Fibromyalgia is emphasized.
Is fibromyalgia a distinct clinical entity? Historical and epidemiological evidence.
  • S. Wessely, M. Hotopf
  • Medicine, Psychology
    Bailliere's best practice & research. Clinical rheumatology
  • 1999
TLDR
Evidence is presented to suggest that fibromyalgia is not a unique clinical entity, but shares much with other medically unexplained syndromes which have more similarities than differences between them.
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