Central role of the proteasome in senescence and survival of human fibroblasts: induction of a senescence-like phenotype upon its inhibition and resistance to stress upon its activation.

Abstract

Normal human fibroblasts undergo a limited number of divisions in culture and progressively they reach a state of irreversible growth arrest, a process termed as replicative senescence. The proteasome is the major cellular proteolytic machinery, the function of which is impaired during replicative senescence. However, the exact causes of its malfunction in… (More)

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@article{Chondrogianni2003CentralRO, title={Central role of the proteasome in senescence and survival of human fibroblasts: induction of a senescence-like phenotype upon its inhibition and resistance to stress upon its activation.}, author={Niki Chondrogianni and Fiona L L Stratford and Ioannis P Trougakos and Bertrand Friguet and A. Jennifer Rivett and Efstathios S. Gonos}, journal={The Journal of biological chemistry}, year={2003}, volume={278 30}, pages={28026-37} }