Central role of the MEK/ERK MAP kinase pathway in a mouse model of rheumatoid arthritis: potential proinflammatory mechanisms.

@article{Thiel2007CentralRO,
  title={Central role of the MEK/ERK MAP kinase pathway in a mouse model of rheumatoid arthritis: potential proinflammatory mechanisms.},
  author={Melissa J Thiel and Caralee J Schaefer and Mark E. Lesch and James L. Mobley and David T. Dudley and Haile Tecle and Stephen D. Barrett and Denis J. Schrier and Craig M. Flory},
  journal={Arthritis and rheumatism},
  year={2007},
  volume={56 10},
  pages={3347-57}
}
OBJECTIVE To evaluate the role of the MEK/ERK MAP kinase pathway in murine collagen-induced arthritis (CIA) using the selective MEK inhibitor PD184352. We examined the effects of the inhibitor in cytokine-stimulated synovial fibroblasts and in cytokine-induced arthritis in rabbits to investigate its antiinflammatory mechanisms. METHODS Murine CIA was used… CONTINUE READING