Central role of soluble adenylyl cyclase and cAMP in sperm physiology.

  title={Central role of soluble adenylyl cyclase and cAMP in sperm physiology.},
  author={Mariano Gabriel Buffone and Eva V Wertheimer and Pablo E Visconti and Dar{\'i}o Krapf},
  journal={Biochimica et biophysica acta},
  volume={1842 12 Pt B},
Cyclic adenosine 3',5'-monophosphate (cAMP), the first second messenger to be described, plays a central role in cell signaling in a wide variety of cell types. Over the last decades, a wide body of literature addressed the different roles of cAMP in cell physiology, mainly in response to neurotransmitters and hormones. cAMP is synthesized by a wide variety of adenylyl cyclases that can generally be grouped in two types: transmembrane adenylyl cyclase and soluble adenylyl cyclases. In… CONTINUE READING


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