Central role of mitochondrial aldehyde dehydrogenase and reactive oxygen species in nitroglycerin tolerance and cross-tolerance.

@article{Sydow2004CentralRO,
  title={Central role of mitochondrial aldehyde dehydrogenase and reactive oxygen species in nitroglycerin tolerance and cross-tolerance.},
  author={Karsten Sydow and Andreas Daiber and Matthias Oelze and Zhiqiang Chen and Michael August and Maria C Wendt and Volker Ullrich and Alexander Muelsch and Eberhard Schulz and John F. Keaney and Jonathan S. Stamler and Thomas F. M{\"u}nzel},
  journal={The Journal of clinical investigation},
  year={2004},
  volume={113 3},
  pages={482-9}
}
Recent studies suggest that mitochondrial aldehyde dehydrogenase (ALDH-2) plays a central role in the process of nitroglycerin (glyceryl trinitrate, GTN) biotransformation in vivo and that its inhibition accounts for mechanism-based tolerance in vitro. The extent to which ALDH-2 contributes to GTN tolerance (impaired relaxation to GTN) and cross-tolerance (impaired endothelium-dependent relaxation) in vivo remain to be elucidated. Rats were treated for three days with GTN. Infusions were… CONTINUE READING
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