Central role of extracellular signal-regulated kinase and Toll-like receptor 4 in IL-10 production in regulatory dendritic cells induced by Trypanosoma cruzi.

@article{Poncini2010CentralRO,
  title={Central role of extracellular signal-regulated kinase and Toll-like receptor 4 in IL-10 production in regulatory dendritic cells induced by Trypanosoma cruzi.},
  author={Carolina Ver{\'o}nica Poncini and Guadalupe Gim{\'e}nez and Carolina Andrea Pontillo and Catalina D Alba-Soto and Elvira Luisa Durante de Isola and Isabel M. Piazz{\'o}n and Stella Maris Gonz{\'a}lez Cappa},
  journal={Molecular immunology},
  year={2010},
  volume={47 11-12},
  pages={1981-8}
}
Several Trypanosoma cruzi molecules that stimulate macrophages activity were described as Toll-like receptor 2 (TLR2) ligands. Besides, the models of dendritic cells (DC) are poorly characterised. We have previously demonstrated that live-trypomastigotes (Tp) plus lipopolysaccharide (LPS) induce DC with tolerogenic properties that produce high levels of interleukin (IL)-10 and an impaired capacity to induce lymphoproliferation. Here, we show that the regulatory phenotype was observed with heat… CONTINUE READING
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