Central role of a bacterial two-component gene regulatory system of previously unknown function in pathogen persistence in human saliva.

@article{Shelburne2005CentralRO,
  title={Central role of a bacterial two-component gene regulatory system of previously unknown function in pathogen persistence in human saliva.},
  author={Samuel A. Shelburne and Paul Sumby and Izabela Sitkiewicz and Chanel N Granville and Frank R Deleo and James M. Musser},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2005},
  volume={102 44},
  pages={16037-42}
}
The molecular genetic mechanisms used by bacteria to persist in humans are poorly understood. Group A Streptococcus (GAS) causes the majority of bacterial pharyngitis cases in humans and is prone to persistently inhabit the upper respiratory tract. To gain information about how GAS survives in and infects the oropharynx, we analyzed the transcriptome of a serotype M1 strain grown in saliva. The dynamic pattern of changes in transcripts of genes [spy0874/0875, herein named sptR and sptS (sptR/S… CONTINUE READING