Central role of Th2/Tc2 lymphocytes in pattern II multiple sclerosis lesions

  title={Central role of Th2/Tc2 lymphocytes in pattern II multiple sclerosis lesions},
  author={Raquel Planas and Imke Metz and Yaneth M Ortiz and N{\'u}ria Vilarrasa and Ilijas Jel{\vc}i{\'c} and Gabriela Salinas-Riester and Christoph Heesen and Wolfgang Br{\"u}ck and Roland Martin and Mireia Sospedra},
  booktitle={Annals of clinical and translational neurology},
OBJECTIVE Multiple sclerosis (MS) is a disease of the central nervous system with marked heterogeneity in several aspects including pathological processes. Based on infiltrating immune cells, deposition of humoral factors and loss of oligodendrocytes and/or myelin proteins, four lesion patterns have been described. Pattern II is characterized by antibody and complement deposition in addition to T-cell infiltration. MS is considered a T-cell-mediated disease, but until now the study of… CONTINUE READING
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International Multiple Sclerosis

  • AH Beecham, NA Patsopoulos
  • 2013

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